Scientists use atomic force microscopes to examine matter such as biological cells and bacteria at the nanoscale. 

Loren set out to develop the fastest one in the world, and achieved this ground-breaking goal in 2014. 

His project is unique in that it can map not only the height of the sample surface but also its stiffness and conductance with nanometre resolution.

The microscope has a touch screen interface so that scientists can use ‘multi-touch’ gestures much like on smartphones to interact with samples in real time. 

This improves usability, makes analysis quicker.and opens up new ways of manipulating samples. And it lets non-skilled operators control the instrument.

Having already invested significant time in his research at the University of Bristol, Loren is now commercialising the project through his company Bristol NanoDynamics. It promises to be even more of a game-changer in future.

Dr Kai Yang has developed an everyday fabric-based electrode for wearable medical devices so that stroke sufferers and people in need of pain relief can get electrical stimulation treatment in a far more practical way than ever before.

Traditional electrodes (made from hydrogel) are not ideal for wearable applications as they are sticky, have a limited lifetime, need to be kept in a sealed bag to stop moisture evaporation, and are incompatible with clothing.

Dr Kai Yang's fabric electrode can be applied on the skin directly without using any gel. Everyday fabrics and clothing items such as an arm band or sleeve can have the electrodes added to suit various needs. The fabric-based electrode is comfortable to wear, easy to use, washable and unobtrusive.

The fabric electrode can be used  to deliver Functional Electrical Stimulation (FES) for stroke rehabilitation; TENS for pain relief (e.g. arthritis, back pain, neck pain) and health monitoring (e.g. ECG, EEG, EMG). 

As a Principal Investigator, Kai has secured £1.1M research funding from the Medical Research Council for a multi-disciplinary team to develop a wearable FES training system for home based stroke rehabilitation using the fabric electrode together with advanced control and sensor technologies. The FES training system will enable stroke survivors to conduct rehabilitation activities without the need of a carer or therapist. 

Daniel is the inventor of RHEON™ and CTO of RHEON LABS.

RHEON is a revolutionary mouldable material that is capable of absorbing high levels of energy in impact, tension and vibration. It uses a property known as strain-rate dependency to allow this material to be flexible in normal wearing, but to stiffen instantaneously and temporarily when subject to an acute energy input. It can be moulded directly onto clothing, incorporated into the fabric as a thread or coating, or laminated onto a material and is both breathable and washable. 

Daniel has worked in the field of energy absorbing systems and their applications for over 15 years, including specialisation work in smart textiles for NASA and sitting on the London 2012 Olympic committee. During his PhD, the fellowship and throughout his work since has built up a significant portfolio of patents which are now being exploited for the sports sector through RHEON LABS Ltd.

The scientists, engineers and designers at RHEON LABS are already engaged with best-in-class brands across a wide spectrum of sports apparel, collaborating with some of the biggest names to integrate RHEON™ into their products to enhance the performance, comfort and protection.

Poised now for rapid growth, Daniel and RHEON LABS are building a team to widen the commercialisation of this exciting technology. Whilst the initial focus is on the sports-apparel sector, there are significant opportunities for applying this potentially life-saving technology in several other sectors such as electronics, healthcare and defence.

Traction

• January 2019: Launched RHEON enhanced helmet with FLY Racing – the best motocross helmet on the market, verified by independent testing
• November 2018: RHEON LABS team grows to 11 full time staff
  
• October 2018: Established RHEON LABS to commercialise Dan’s patent portfolio
• August 2018: Launched RHEON enhanced helmet with Ruroc – one of the UK’s fastest growing brands disrupting the snowsports helmet sector

Cold, uncomfortable draughts prevent many from enjoying warmer, drier homes especially during winter months. Underfloor insulation is an effective solution, but applying it can be a challenge. However, engineers at Q-Bot have developed a novel way to do this, creating a more efficient method to keep older homes warm.

Q-Bot blends expert knowledge in energy-efficient buildings with robotics and artificial intelligence. The company’s world-leading technology is a small robot that can easily access the space between floorboards and building foundations. Once there, it can be operated remotely to apply layers of insulating material, to make draughty, older homes more airtight and energy efficient. In other words, they become cosier, warmer and its cheaper to keep them that way.  

The technology has been continually developed with input from consumers, leading to a product that is both ready for market and more efficient. Q-Bot insulation can reduce heat loss through suspended timber floors by up to 90%. Supported by the SME Leaders Programme, Mathew Holloway, CEO, is now scaling up the company and rolling the service out with social landlords across the UK.

Q-Bot is also looking at how its expertise can benefit other areas of the construction industry, and Mathew’s vision is to strategically position the company as a leader in smart tools for the construction industry that empower workers and make them more productive.

Jon has developed software to help drug developers predict the effects of new drugs on auto-immune diseases, such as rheumatoid arthritis and multiple sclerosis. 

His software is capable of integrating far more data and concepts than the systems currently used by drug developers creating clinical trials of new products. The increased data input through Jon's system results in improved confidence in computer simulations, cost savings and quicker speed to market for new drug releases. 

Jon is Professor of Intelligent and Adaptive Systems at the University of York, where his research focuses on building computer models of immune function in the human body. He is the founder of SimOmics, a spin out of the University of York, which is expanding on these developments.

Philip is the founder of Synaptec Ltd and is pioneering new photonic sensor and interrogator designs for complex modern energy systems like smart grids. 

His technology eliminates the need to duplicate expensive measurement hardware. This is achieved by getting simultaneous measurements of electrical parameters from across the power grid, without bandwidth limitations and with minimal infrastructure.

Synaptec reduces electrical power transmission costs through reducing outages, preventing circuit damage, and minimising civil works. These low-carbon technologies are what will underpin electric power generation and distribution in the future.

He is also working with the industry to improve power system protection capabilities by removing the bottlenecks that often take place with present methods.

Working in tandem with PhD student Robert Rudolf, Reuben developed the first instance of technology that will allow energy consumed by mains connected equipment to be measured without the need for a monitor between the equipment and the wall socket.

The technology uses state of the art sensors with elegant calibration and measurement algorithms.

This resulted in an innovative new device that is a non-invasive multi-core current clamp which can be fitted around a cable and removed with ease. This approach removes the need to access sockets and to power down equipment for the fitting process.

Reuben's spinout company, Joulo, was acquired in 2015 Quby, Europe’s leading develop of smart thermostats and energy displays. 

Following the sale of Joulo, Reuben co-founded Future Worlds, an on-campus startup incubator helping aspiring entrepreneurs to change the world with their ideas at the University of Southampton.

Major advances in fabrication techniques now allows the building of new materials and devices on an atomic or molecular scale. These engineered materials can offer great advantages such as increased energy efficiency, strength, antibacterial properties and more. Their potential is vast, and very exciting to a range of industry sectors from medicine to aircraft manufacture.

To use  - and continue to advance - the possibilities of these nano-engineered materials requires tools that can efficiently measure and characterise their properties.

Oliver is working to transform high-speed atomic force microscopy (HSAFM) into a diagnostic and fabrication tool to do precisely this. 

His work is up to the challenge posed by imaging nano scale structures over sample areas which are industrially relevant. HSAFM is capable of imaging areas several thousand times faster than conventional atomic force microscopy (AFM). 

Oliver's research at the University of Bristol will provide a tool to produce terra-pixel sized 3D images of surfaces. It will also be capable of rapidly prototyping nano structures over centimetre-sized areas in a matter of hours. 

Mapping, measuring and manufacturing nanostructures via high-speed atomic force microscopy is now a possibility!

Ian is the Managing Director of TribeHive, a University of Sussex spin-out focussing on software to overcome the problem of poor smartphone data connectivity in crowded places. 

His innovation lets individual smartphone apps crowd-share data bandwidth by building a network directly between the mobile devices. This network is then used as the basis for distributing information.

Using this technology, mobile apps can reliably deliver match-related content and social media feeds to football fans in stadiums. 

The system is now in place in a large number of professional football clubs, and the commercial rights in the sports market have now passed on to the company InCrowd Sports. Working with TribeHive, Ian continues to develop other opportunities for the technology.

David Gammon founded Rockspring in 2002 after 17 years of investment banking experience.

Rockspring provides advice and capital to disruptive technology companies from seed through scale up. His family are the benefactors of the JC Gammon Launchpad Award run by the Enterprise Hub.

David is a non-executive director at Raspberry Pi Trading Limited, Accesso Technology Group plc and Frontier Developments plc. 

Suranga has long experience as an engineer and entrepreneur. He founded Blinkx - an intelligent search engine for video and audio content - in 2004. He led Blinkx as CEO for eight years as well as taking it public in 2007. He is widely regarded as an expert on the convergence of the web, television and online advertising.

 Before his work with Blinkx, Suranga was US Chief Technology Officer of Autonomy where he was mentored by Mike Lynch and led the effort to enable Autonomy’s software to work in highly distributed environments. Suranga joined Balderton as a General Partner in 2014.

An accomplished speaker and commentator on the overlap between technology and media, Suranga has been elected by the World Economic Forum as one of its Young Global Leaders. He was also included in the Top 10 leaders in Science and Innovation by The Observer’s Future 500 list, and was a recipient of the Royal Academy of Engineering’s Silver Medal in 2012. Suranga was elected a Fellow of the Royal Academy of Engineering (FREng) in 2012.

Anne is a prominent venture capitalist and European technology investor who has been Chief Executive of Amadeus Capital Partners from 1997. As a co-founder in the organisation, Anne’s role combines her experience as a scientist, operating manager and venture capitalist.

Anne began her career in manufacturing with Cummins Engine Company before moving into investment as a business angel. She was also Chief Operating Officer of Virtuality Group, which had been one of her investee companies.

Anne has held a number of high profile advisory positions, having served as Chairman of the British Venture Capital Association in 2004, and as a non-executive director of the UK Technology Strategy Board from 2005-2012. In 2008 Anne led the establishment of the Glover advisory committee for the Chancellor of the Exchequer, reporting on government procurement from SMEs. She is also a member of the European Research and Innovation Advisory Board. Anne was awarded a CBE for services to business in 2006 and was elected an Honourary Fellow of the Royal Academy of Engineering in 2008.

Chair of the Enterprise Committee and a long-standing Academy Fellow, Ian has played a prominent role in establishing the Enterprise Hub. His track record of helping businesses in the engineering and life science sectors transform their approach and improve their vision, ambition, business models and enterprise value is an invaluable resource.

Ian is currently Managing Director of contract R&D company Arcinova and is also the Managing Partner at investment and advisory firm Shott Trinova LLP. Prior to his specialist investment work at Shott Trinova, Ian was the founder and CEO of Excelsyn, which was sold to an American multinational in 2010. Earlier in his illustrious career he held numerous senior executive positions at multinational life science companies across the globe.

Ian has a wealth of experience with major industry bodies. He is currently the Chair of the UK government’s Leadership Forum for Industrial Biotechnology and a Governing Board Member of Innovate UK. Ian is also Visiting Professor at Oxford, Nottingham and Newcastle Universities.

Read Ian's blog about the Hub's new home.

Dick Whittington is a serial entrepreneur, business mentor and investor, focusing on the software industry and digital marketplaces, with over thirty years of experience in business. His experience has included co-founding a successful international software business recognised in UK through three Queen's Awards covering both Innovation and International Trade. 

In 2012 he was elected Fellow of the Royal Academy of Engineering where he plays an active role including as a mentor for early-stage technology startups and spinouts through its highly successful Enterprise Hub. From 2015 Dick has been Visiting and Honorary Professor of Business Innovation at the University of York, where he has developed and delivered a respected course in Digital Innovation and Entrepreneurship for students and staff. He is also an active mentor and angel investor within several London and regional technology accelerator programmes. 

Prior to pursuing business interests, Dick lectured in Computer Science at the University of York. He managed a successful research team and published a number of research papers and books, including Database Systems Engineering (1987), which became a standard text within many universities. He also contributed to several significant texts including The Software Life Cycle (1990) and the Software Engineers' Reference Book (1991).

Phil is an active Cambridge-based angel investor where he chairs, coaches, invests in and helps communications, software and device companies. He is a frequent speaker on a broad range of entrepreneurial topics and an advisor to universities on the commercialisation of their IP.

In 1999 Phil co-founded the spin-out Cambridge Silicon Radio (CSR) and as managing director, helped to grow CSR plc from a startup of nine people into a highly successful FTSE 250 listed fabless semiconductor company. In 2003, CSR plc had become the largest global market supplier of Bluetooth chips. By 2015, they had shipped three billion chips, employed more than 2,000 people in 23 locations and was acquired by US-based Qualcomm for $2.5 billion.

Phil has been a research fellow at AERE, a chief research engineer at Standard Telecommunication Laboratories, UK Alvey & CEC ESPRIT project manager and a telecoms practice manager at Arthur D Little’s Cambridge Consultants, from which he spun-out CSR plc.

Phil was a recipient of the MacRobert Award in 2005 along with CSR colleagues, for the world's first high-volume single chip Bluetooth device. He was elected as a Royal Academy of Engineering Fellow in 2017 and holds an honorary doctorate from the University of Essex.

Formerly the UK Innovation Director for Atkins, Elspeth is the CEO and Founder of IAND, a digital platform that helps major enterprises manage multiple suppliers. 

Initially graduating as a chemist, Elspeth later turned her hand to transport and urban design, demonstrating business and technical leadership on over 100 transport planning projects both nationally and around the world.

Elspeth chairs the Enterprise Hub’s Innovators Network and is a judge for the Hub’s Launchpad Competition. She is also a member of the Royal Academy of Engineering’s Diversity and Inclusion Committee.

In 2017, Elspeth was awarded a Member of the Order of the British Empire (MBE) for her services to Engineering and Enterprise. 

Nigel’s career has involved working in the UK and the Netherlands for Unilever and Wellcome Research. While abroad, he built and operated the first large-scale Dutch facility for the manufacture of the genetically engineered protein alpha-galactosidase. Later, he led the process design for Wellcome’s WelGen interferon manufacturing plant in the USA.

Nigel has served as a co-founding non-executive director for two manufacturing SMEs, Cobra Biomanufacturing Plc (which was listed on AIM) and Angel Technology Ltd. The latter was awarded the Queen’s Award for Innovation in 2006 and the International Sial d’Or prize for the most innovative new UK nutritional product at the Paris International Food Conference 2004. Currently he is Head of the Department of Chemical Engineering and Biotechnology at Cambridge University.

Nigel was elected a Fellow of the Royal Academy of Engineering (FREng) in 2004.

Saeed is Technical Director at the prosthetic manufacturer Blatchford, winners of the 2016 RAEng MacRobert Award.

He has built a highly successful career based on outstanding innovation, product development and scientific research in the field of prosthetics. His work saw the company shortlisted for the Royal Academy of Engineering MacRobert Award in 2010.

Saeed has provided invaluable advice to emerging innovators in his field, such as negotiating with investors, creating new business cases and establishing alternative investment return strategies,  IP issues, and how to identify new needs and opportunities in the market to develop a road map of future products.

He  was elected a Fellow of the Royal Academy of Engineering (FREng) in 2012.