The fourth industrial revolution is changing every element of enterprise. Companies that innovate throughout the value chain, such as Tesla or Dollar Shave Club, are achieving breakthrough growth, 

While sales and marketing, product development, service and support and back office functions have seen significant digitisation and investment, manufacturing has been left behind. Often not integrated to the wider enterprise and with significant investments in legacy equipment, manufacturing has historically been a very hard environment in which to scale change. There is now a huge opportunity to drive digitisation and innovation in the supply chain to gain a competitive edge. 

George is founder of Make-Sense, which is building on five years of industrial Internet of Things experience in the LPG sector. Make-Sense provides a data collection and analytics platform that empowers the whole supply chain from the shop floor to the top floor to drive radical efficiency and growth improvements.

Make-Sense is working with several of the world’s largest consumer goods brands to radically transform how they can leverage manufacturing as a core part of their growth and efficiency strategies.

Anaemia is defined by a low red blood cell count. It is the world’s second leading cause of disability, with 1.6 billion sufferers globally. Although it has multiple causes, once they are identified anaemia is often curable.

Based on proprietary technology developed at Imperial College, Toby’s start-up company Eva Diagnostics is developing two affordable handheld anaemia diagnostic devices. 

The first one is AnemiPoint, which can be used to identify the presence of anaemia in patients. The other device AnemiStat will identify different types of anaemia. 

This is a market-first development in point-of-care anaemia diagnosis that enables clinicians to provide tailored treatments for patients. Eva Diagnostics plans to focus on the global market and the $1 billion or more spend on anaemia-related costs.

Over 100,000 tents go to landfill sites each year in the UK alone, partially because a staggering one in five tents is left behind by UK festival-goers. This tremendous annual wastage has long-term environmental damage plus also leads to expensive clean-up bills and landfill taxes for festival organisers.

Architectural Studies student Amanda Campbell founded Comp-A-Tent to create the world’s first fully compostable, plant-based tent.

Her invention can be disposed of with commercial food waste, potentially saving festival organisers millions in clean-up costs and landfill taxes. 

She has engineered the plastic to be weather-resistant, comfortable, light and cheaper to make than traditional tents.  

Her innovation has many other potential applications, from biodegradable hammocks and to compostable furniture for weekend art installations and food festivals.

The problem

Open surgery is the current standard for preparing patients for dialysis and bypassing blocked peripheral arteries. High failure rates (approximately 50%) in both cases present a serious danger to life and require repeat procedures, for US dialysis patients alone this adds up to $4.6 billion per year.

The solution

Sorin Popa, founder of Pathfinder Medical, developed an electronic catheter guidance system that enables clinicians to connect blood vessels in a minimally invasive way, eliminating the need for open surgery and improving outcomes for vascular procedures. This technology has the potential to reduce the cost and trauma associated with procedures to treat those with renal failure and peripheral arterial disease.

Worldwide 3.4 million patients have end stage kidney disease and require their blood to be routinely filtered externally through haemodialysis.

This requires surgery to open up the arm and prepare patients’ blood vessels by forming a connection between an artery and a vein (known as a fistula or vascular access site). Pathfinder Medical’s catheter system can be used to connect blood vessels using a small covered tube known as a ‘stent graft’.  

This technology enables patients to receive kidney dialysis without surgery. It can also be used to bypass blocked vessels for those with peripheral arterial disease which affects over 200 million patients globally.

The technology improves outcomes for patients by reducing stress, discomfort and the risk of vascular access problems. It brings cost saving to healthcare providers by improving the efficiency of procedures and reducing the likelihood of costly repeat procedures. 

The global market for the technology is worth over £3.8 billion annually. In the UK, the solution could save the NHS an estimated £45 million per annum on kidney dialysis alone.

Traction

• 2018: Pathfinder Medical receives ISO 13485 accreditation and starts developing devices for a first in man clinical trial
• 2017: UK patent GB2536362 (B) is granted to Pathfinder Medical for the catheter guidance system
  
• 2016: Sorin's technology awarded the James Dyson Award International Top 20
• 2015: awarded a £166,000 'Smart Award’ from Innovate UK and a £1 million grant to develop the technology in partnership with Imperial College London

A 2016 Enterprise Fellowship was awarded to Sorin to support the growth of his start-up as it trials its technology in preparation for commercialisation.

The problem

Surgeons need accurate, objective information to support decision making during minimally invasive surgery. They regularly rely on sight for intricate processes such as placing stents - small metallic tubes - in blood vessels in brain aneurysm patients. Better information could improve patient outcomes and save millions of pounds from being spent on corrective surgeries.

The Solution

After her PhD at Oxford in Biomedical Engineering, Katerina Spranger has founded Oxford Heartbeat – a start-up company that has developed a medical device that accurately simulates the behaviour of medical devices inside patient’s brain during surgery.

Engineered to achieve extremely high levels of accuracy, the device improves surgeons’ ability to choose the correct stent for every individual patient. This aims to reduce surgery times, improve patient outcomes, decrease the likelihood of repeat surgeries, and save costs for hospitals and wider society.

The technology has been designed for easy and intuitive use by surgeons. By combining accessibility with precision, this virtual platform has the potential to become an essential tool for minimally invasive brain surgery. The start-up’s plans include exploring the use of its technology to optimise other types of surgery in the future.

Traction

• January 2019: Awarded with the Innovate UK Biomedical Catalyst Grant Award
• July 2018: Awarded from SBRI Healthcare, an NHS England funded initiative, to further develop a novel technology
• July 2018: Royal Academy of Engineering Blavatnik Alumni Award winner
•  May 2018: Invited to join the Philips HealthWorks Start-up Program
  
• March 2018: Won “Best Healthcare start-up of 2018” by WIRED Magazine
• February 2018: Awarded the NIHR i4i Connect grant

Katerina was awarded the 2017 Enterprise Fellowship to continue developing this technology and her start-up, Oxford Heartbeat.

When Disabled Student Allowance funding for transcription services and note-takers was abolished in 2016, universities scrambled to find ways of supporting disabled students. Existing transcription services were prohibitively expensive and disabled students were at risk of missing out on hours of lectures each week.

Dr Yunjia Li and Professor Mike Wald founded Synote to address the need for accessible lecture videos. Synote is designed to deliver videos that are less costly and produced quicker than traditional methods. The system automatically generates an interactive transcript and captions from a video or audio copy of a lecture, and can integrate with university lecture-capture systems. 

Synote can process the many tens of thousands of lectures given at universities each year, and users can quickly search through their transcripts for specific topics. The system even creates screenshots for each part of the lecture which can be printed with the transcript. Synote can also be used to automatically translate lecture transcripts into other languages, which can open up university education to a much broader base of international students. A unique ‘feedback loop’ enables students to correct speech recognition transcription errors to continually improve the transcript’s accuracy as the system ‘learns’ how to match new words with sounds.

Southampton University has invested significantly in Synote and other leading universities have expressed great interest. The ability to improve the learning experience of all students and particularly students with difficulties hearing or understanding lecturers, taking notes or attending lectures is of great value and significance to these institutions.

Although Synote was originally developed for universities, it can reduce the cost of captions and transcriptions in any business where video or audio recordings are used.

A child dies of malaria every two minutes, often because they arrive at hospital too late to be saved. The disease is one of the world’s most deadly, with approximately 207 million infections and more than 600,000 deaths each year. Drug resistance is spreading globally and many strains of the disease are untreatable. 

George developed the MediSieve system to tackle this terrible situation. MediSieve uses haemofilter technology which ‘sieves’ the blood rapidly and safely reduces malarial parasites from a patient's system. This novel technology requires no drugs or chemicals and can be used to treat any malaria patient, including drug-resistant and other untreatable cases, keeping patients alive and symptom-free indefinitely.

Used either in isolation or as a stand-alone treatment, the haemofilter removes malaria infected cells directly from the bloodstream in a dialysis-like process. 

In severe cases, MediSieve could reduce mortality and recovery times; in non-severe cases, patients could recover in hours rather than days as the efficacy of drugs is increased and their side-effects eliminated.

Following extensive trials, MediSieve products will be commercially available in the next couple of years.

 Christine Boyle was working as the managing director of her family roofing business when she realised that there was huge potential for the collection of solar heat energy on the large commercial flat roofs that her company constructed. Solar thermal is a renewable energy that is 70% efficient, produces the lowest carbon emissions, and is easily generated on site, but had not been widely used because of its expense, weight and inflexibility with existing architecture.

 Christine set up Senergy Innovations to create the next generation of solar thermal panels. She worked with Queen’s University Belfast and the University of Ulster to produce the product, ensuring that the renewable energy panels addressed the problems that previous solar thermal panels faced as well as making panels that appealed to consumers and architects.

 Senergy Innovations’ solar thermal panel is made from 100% polymer plastic, making it 50% cheaper to manufacture and install than existing products. The panels incorporate carbon nanotube materials that enhance the thermal performance and mechanical strength, which ensures that they are durable. The module panels are lightweight, and allow integrations with both existing and new buildings, so that renewable thermal energy can be easily generated on site.

 Senergy’s solar thermal panels are affordable, durable and easy to integrate, creating a renewable energy solution that is competitive with gas and oil. 

The problem

A lack of smart energy storage options is linked to poor energy distribution in developing countries and inefficient energy management in developed ones.

The solution

Dr Enass Abo-Hamed, CEO and Co-Founder of H2GO Power, has engineered new hydrogen-based energy storage units that use patented catalyst that allow energy to be released on demand.

This clean, low-cost energy storage solution has the capacity to store five to ten times as much energy as their battery equivalents. It could impact energy storage at every scale, from the provision of low-weight energy for drones to large-scale energy storage for national grids.

As an innovator with a strong drive to generate social impact, Enass Abo-Hamed aims to harness the technology’s abilities to utilise excess renewables, and facilitate reliable distribution of power in countries where energy supply is intermittent.

Initiatives are underway to penetrate the fast-growing, green energy market in remote islands, where H2GO Power’s Hydrogen based fuel units would offer a clean, low-cost solution for round-the-clock power.

There is also significant industrial interest from companies keen to explore other ways this disruptive technology can support smarter energy management. 

Traction

• July 2017: Funding from the Climate - Knowledge & Innovation Community

Enass was awarded the 2017 Enterprise Hub Fellowship to help grow and develop her start-up, H2GO Power.

David Gammon founded Rockspring in 2002 after 17 years of investment banking experience.

Rockspring provides advice and capital to disruptive technology companies from seed through scale up. His family are the benefactors of the JC Gammon Launchpad Award run by the Enterprise Hub.

David is a non-executive director at Raspberry Pi Trading Limited, Accesso Technology Group plc and Frontier Developments plc. 

Suranga has long experience as an engineer and entrepreneur. He founded Blinkx - an intelligent search engine for video and audio content - in 2004. He led Blinkx as CEO for eight years as well as taking it public in 2007. He is widely regarded as an expert on the convergence of the web, television and online advertising.

 Before his work with Blinkx, Suranga was US Chief Technology Officer of Autonomy where he was mentored by Mike Lynch and led the effort to enable Autonomy’s software to work in highly distributed environments. Suranga joined Balderton as a General Partner in 2014.

An accomplished speaker and commentator on the overlap between technology and media, Suranga has been elected by the World Economic Forum as one of its Young Global Leaders. He was also included in the Top 10 leaders in Science and Innovation by The Observer’s Future 500 list, and was a recipient of the Royal Academy of Engineering’s Silver Medal in 2012. Suranga was elected a Fellow of the Royal Academy of Engineering (FREng) in 2012.

Anne is a prominent venture capitalist and European technology investor who has been Chief Executive of Amadeus Capital Partners from 1997. As a co-founder in the organisation, Anne’s role combines her experience as a scientist, operating manager and venture capitalist.

Anne began her career in manufacturing with Cummins Engine Company before moving into investment as a business angel. She was also Chief Operating Officer of Virtuality Group, which had been one of her investee companies.

Anne has held a number of high profile advisory positions, having served as Chairman of the British Venture Capital Association in 2004, and as a non-executive director of the UK Technology Strategy Board from 2005-2012. In 2008 Anne led the establishment of the Glover advisory committee for the Chancellor of the Exchequer, reporting on government procurement from SMEs. She is also a member of the European Research and Innovation Advisory Board. Anne was awarded a CBE for services to business in 2006 and was elected an Honourary Fellow of the Royal Academy of Engineering in 2008.

Chair of the Enterprise Committee and a long-standing Academy Fellow, Ian has played a prominent role in establishing the Enterprise Hub. His track record of helping businesses in the engineering and life science sectors transform their approach and improve their vision, ambition, business models and enterprise value is an invaluable resource.

Ian is currently Managing Director of contract R&D company Arcinova and is also the Managing Partner at investment and advisory firm Shott Trinova LLP. Prior to his specialist investment work at Shott Trinova, Ian was the founder and CEO of Excelsyn, which was sold to an American multinational in 2010. Earlier in his illustrious career he held numerous senior executive positions at multinational life science companies across the globe.

Ian has a wealth of experience with major industry bodies. He is currently the Chair of the UK government’s Leadership Forum for Industrial Biotechnology and a Governing Board Member of Innovate UK. Ian is also Visiting Professor at Oxford, Nottingham and Newcastle Universities.

Read Ian's blog about the Hub's new home.

Dick Whittington is a serial entrepreneur, business mentor and investor, focusing on the software industry and digital marketplaces, with over thirty years of experience in business. His experience has included co-founding a successful international software business recognised in UK through three Queen's Awards covering both Innovation and International Trade. 

In 2012 he was elected Fellow of the Royal Academy of Engineering where he plays an active role including as a mentor for early-stage technology startups and spinouts through its highly successful Enterprise Hub. From 2015 Dick has been Visiting and Honorary Professor of Business Innovation at the University of York, where he has developed and delivered a respected course in Digital Innovation and Entrepreneurship for students and staff. He is also an active mentor and angel investor within several London and regional technology accelerator programmes. 

Prior to pursuing business interests, Dick lectured in Computer Science at the University of York. He managed a successful research team and published a number of research papers and books, including Database Systems Engineering (1987), which became a standard text within many universities. He also contributed to several significant texts including The Software Life Cycle (1990) and the Software Engineers' Reference Book (1991).

Mike is a leading Silicon Fen-based entrepreneur. He is best known as a co-founder of enterprise software company Autonomy and founder of Invoke Capital, which invests in promising British technology businesses.

A celebrated technologist with a proven track record of identifying and monetising fundamental technologies, Mike has been recognised as one Britain’s most successful entrepreneurs in the industry. The Times has referred to Mike as “the closest thing Britain has to its own Bill Gates”.

Mike studied Information Sciences, received a PhD and held a research fellowship in adaptive pattern recognition at Cambridge University. After co-founding Autonomy he served as CEO for over fifteen years, during which time it became one of the UK’s most successful technology companies on the FTSE100. His latest venture Invoke Capital has raised over $1billion since its launch in 2012 and made its first investment in the cyber-security firm Darktrace in 2013 ,now valued at $800m, other investment areas include machine learning to automate legal functions, augmented reality and genomics.

Mike has received a number of prestigious honours throughout his career. He was named Entrepreneur of the Year in 1999 by the Confederation of British Industry; presented with an award for Autonomy as a technology pioneer by The World Economic Forum in 2000, and awarded an OBE in 2006 for Services to Enterprise. He has been a Fellow of the Royal Academy of Engineering from 2008.

Formerly the UK Innovation Director for Atkins, Elspeth is the CEO and Founder of IAND, a digital platform that helps major enterprises manage multiple suppliers. 

Initially graduating as a chemist, Elspeth later turned her hand to transport and urban design, demonstrating business and technical leadership on over 100 transport planning projects both nationally and around the world.

Elspeth chairs the Enterprise Hub’s Innovators Network and is a judge for the Hub’s Launchpad Competition. She is also a member of the Royal Academy of Engineering’s Diversity and Inclusion Committee.

In 2017, Elspeth was awarded a Member of the Order of the British Empire (MBE) for her services to Engineering and Enterprise. 

Nigel’s career has involved working in the UK and the Netherlands for Unilever and Wellcome Research. While abroad, he built and operated the first large-scale Dutch facility for the manufacture of the genetically engineered protein alpha-galactosidase. Later, he led the process design for Wellcome’s WelGen interferon manufacturing plant in the USA.

Nigel has served as a co-founding non-executive director for two manufacturing SMEs, Cobra Biomanufacturing Plc (which was listed on AIM) and Angel Technology Ltd. The latter was awarded the Queen’s Award for Innovation in 2006 and the International Sial d’Or prize for the most innovative new UK nutritional product at the Paris International Food Conference 2004. Currently he is Head of the Department of Chemical Engineering and Biotechnology at Cambridge University.

Nigel was elected a Fellow of the Royal Academy of Engineering (FREng) in 2004.

Saeed is Technical Director at the prosthetic manufacturer Blatchford, winners of the 2016 RAEng MacRobert Award.

He has built a highly successful career based on outstanding innovation, product development and scientific research in the field of prosthetics. His work saw the company shortlisted for the Royal Academy of Engineering MacRobert Award in 2010.

Saeed has provided invaluable advice to emerging innovators in his field, such as negotiating with investors, creating new business cases and establishing alternative investment return strategies,  IP issues, and how to identify new needs and opportunities in the market to develop a road map of future products.

He  was elected a Fellow of the Royal Academy of Engineering (FREng) in 2012.